Lomibuvir
Cat. No. :YN250839
CAS No. :1026785-55-6
86-020-82000279
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order@ubiochem.com| Product Name: | Lomibuvir |
| CAS NO.: | 1026785-55-6 |
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| Molecular Weight: | 445.61 |
| Molecular Formula: | C₂₅H₃₅NO₄S |
| SMILES: | O=C(C1=C(N([C@@H]2CC[C@@H](O)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of theHCV NS5B polymerase (RdRp)with aKdof 17nM. Lomibuvir inhibits the 1b/Con1HCVsubgenomic replicon with an EC50 of 5.2nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather th and e novo-initiated RNA synthesis. |
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