Tricin is a natural flavonoid present in large amounts in rice bran. Tricin can inhibithuman cytomegalovirus (HCMV)replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregu...
Enocitabine is a nucleoside analog, and is a potentDNA replicationinhibitor, and a DNA chain terminator. Enocitabine inhibits the replication ofhuman cytomegalovirus. Enocitabine has antileukemic and antiviral activities .
Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
B220 is an antiviral agent which can inhibit the growth ofHSV-1,HSV-2 and human cytomegalovirus(CMV).
Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.
Valganciclovir, the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC50 of 3nM. Maribavir has potent antiviral activity againstHCMV and Epstein-Barr virus (EBV).
Tomeglovir is a potent anti-CMVagent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34μM and 0.039μM for HCMV and MCMV.
Artemisone (Artemifone) is a potent and semi-syntheticantimalarial, inhibitsP. falciparumstrains, with a mean IC50 of 0.83nM. Artemisone is also a potent inhibitor ofhuman CMV.
Braco-19 is a potenttelomerase/telomereinhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding lig and , stabilizing G-quadruplexes formation at the 3V telomeric DNA overh...
Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV),...
Letermovir is a novel inhibitor ofCMV, which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8μM forCKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication ofHSV-1(I...
Braco-19 trihydrochloride is a potenttelomerase/telomereinhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding lig and , stabilizing G-quadruplexes formation at the 3V telom...
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