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ALK

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN440429 6-Demethoxytangeretin 6601-66-7

    6-Demethoxytangeretin is a citrus flavonoid isolated fromCitrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast ce...

  • YN440313 ALK inhibitor 1 761436-81-1

    ALK inhibitor 1 (compound 17) is a potent pyrimidinALKinhibitor. ALK inhibitor 1 is a potent inhibitor oftestis-specific serine/threonine kinase 2(TSSK2;IC50=31nM) and focal adhesion kinase(FAK;IC50=2nM).

  • YN440314 ALK inhibitor 2 761438-38-4

    ALK inhibitor 2 (compound 18) is a potent pyrimidinALKinhibitor. ALK inhibitor 2 is a potent inhibitor oftestis-specific serine/threonine kinase 2(TSSK2;IC50=37nM) and focal adhesion kinase(FAK;IC50=5nM).

  • YN440051 NVP-TAE 684 761439-42-3

    TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor with IC50 of 3 nM in a cell-free assay, 100-fold more sensitive for ALK than InsR.

  • YN440407 Crizotinib 877399-52-5

    Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively.

  • YN440094 A 83-01 909910-43-6

    A 83-01 is a potent inhibitor of TGF-β type I receptorALK5 kinase, type I nodal receptorALK4 and type I nodal receptorALK7, with IC50s of 12nM, 45nM and 7.5nM against the transcription induced byALK5,ALK4 and ...

  • YN440335 Ceritinib 1032900-25-6

    Ceritinib (LDK378) is potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Phase 3.

  • YN440267 ASP3026 1097917-15-1

    ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1.

  • YN440240 GSK1838705A 1116235-97-2

    GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.

  • YN440226 Brigatinib 1197953-54-0

    Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.

  • YN440273 ALK-IN-1 1197958-12-5

    AP26113-analog (ALK-IN-1) is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR.

  • YN440237 Alectinib 1256580-46-7

    Alectinib (CH5424802) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.

  • YN440238 Alectinib Hydrochloride 1256589-74-8

    Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

  • YN440334 AZD-3463 1356962-20-3

    AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.

  • YN440348 HG-14-10-04 1356962-34-9

    HG-14-10-04 is an inhibitor of ALK .

  • YN440363 X-376 1365267-27-1

    X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer.

  • YN440336 Ceritinib dihydrochloride 1380575-43-8

    Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and ...

  • YN440350 CEP-37440 1391712-60-9

    CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3nM (FAK) and 120nM(ALK cellular IC50 in 75% human plasma). Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a du...

  • YN440408 Crizotinib hydrochloride 1415560-69-8

    Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respecti...

  • YN440198 Lorlatinib 1454846-35-5

    PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. Phase 1.

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