Karanjin is a major active furanoflavonol constituent ofFordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasingAMPKactivity. Karanjin can induce cancer cell death through cell cycle arrest ...
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of theAMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AM...
Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin indu...
Buformin (1-Butylbiguanide) is a potent and orally active biguanideantidiabetic agent, anAMPKactivator. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activi...
Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.
Buformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent and orally active biguanideantidiabetic agent, anAMPKactivator. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in v...
AICAR (Acadesine), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.
Nepodin (Musizin) is aquinone oxidoreductase (PfNDH2)inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiab...
Kahweol is one of the consituents of the coffee fromCoffea Arabicawith anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibitsadipogenesis and increase glucose uptake by AMP-activated protein kinase (A...
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor T...
6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a ...
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.
COH-SR4 is anAMPKactivator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation, and is promising ...
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activatesAMPK and inhibits inflammatory signaling pathways includingNF-κB and MAPKpathways.
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