Rottlerin, a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porci...
Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activi...
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. Daphnoretin inhibits the proliferation, invasion, and migration of tumor cell...
ζ-Stat (NSC37044) is a specific and atypicalPKC-ζinhibitor, with an IC50 of 5μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro.
Decursin ((+)-Decursin) is a cytotoxic agent and a potentprotein kinase Cactivator from the Root ofAngelica gigas. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. ...
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potentprotein kinase C (PKC)inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochlo...
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced fromGlycine maxwith antioxidant, and anti-cancer activities.
Desmethylglycitein binds directly toCDK1 and CDK2in vivo, resulting in the suppres...
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potentprotein kinase C (PKC)inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regula...
ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypicalPKC-ζinhibitor, with an IC50 of 5μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitr...
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependentPKCantagonist, with an IC50 of 0.7μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhi...
Cercosporin is produced by a plant pathogen,Cercosporakikuchii, and theelsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial ...
Ionomycin (SQ23377) is a potent, selectivecalcium ionophore and an antibiotic produced byStreptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotesapoptos...
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-inducedPKCactivation with IC50s of 0.85 and 1.25μM, respectively, and has antitumor and antiinflammatory activity.
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