YN350218 Lidocaine hydrochloride 73-78-9

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

YN350217 Lidocaine 137-58-6

Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

YN350270 2,5-Dihydroxyacetophenone 490-78-8

2,5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and...

YN350106 Xantocillin 580-74-5

Xanthocillin is a marine agent extracted from Penicillium commune, inducesautophagythrough inhibition of theMEK/ERKpathway.

YN350229 Corynoxeine 630-94-4

Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC ...

YN350253 Enniatin B 917-13-5

Enniatin B is aFusariummycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113μM in an enzyme assay using rat liver microsomes. Enniatins B decreases the activation ofERK(...

YN350117 Urolithin B 1139-83-9

Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα. Urolithin B suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphoryla...

YN350201 trans-Zeatin 1637-39-4

Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.

YN350005 TBHQ 1948-33-0

TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation ofNrf2. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydroc...

YN350260 Enniatin A1 4530-21-6

Enniatin A1 isolated fromFusariummycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction ofapoptosis...

YN350271 Pamoic acid disodium 6640-22-8

Pamoic acid disodium is a potentGPR35agonist with an EC50 value of 79nM. Pamoic acid disodium inducesGPR35internalization and activatesERK1/2withEC50values of 22nM and 65nM, respectively. Pamoic acid disodium potently...

YN350198 Tauroursodeoxycholate 14605-22-2

Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson'...

YN350254 Enniatin B1 19914-20-6

Enniatin B1 is aFusariummycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. E...

YN350259 Asperulosidic Acid 25368-11-0

Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related t...

YN350227 Pachymic acid 29070-92-6

Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibitsAkt and ERKsignaling pathways.

YN350262 Pseudocoptisine acetate 30426-66-5

Pseudocoptisine acetate, a quaternary alkaloid with a benzylisoquinoline skeleton, is isolated from the tubers ofCorydalis turtschaninovii. Pseudocoptisine acetate shows anti-inflammatory properties.

YN350239 Theaflavin 3,3'-digallate 30462-35-2

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse s...

YN350237 Magnolin 31008-18-1

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.

YN350219 Honokiol 35354-74-6

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

YN350199 Tauroursodeoxycholate Sodium 35807-85-3

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.