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> Products > Inhibitors & Agonists > Protein Tyrosine Kinase/RTK > FAK

Chemical structure


Product Name

CAS no.


  • YN440427 Fangchinoline 436-77-1

    Fangchinoline is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.

  • YN440220 Petunidin chloride 1429-30-7

    Petunidin chloride is an O-methylated anthocyanidin derived fromdelphinidinthat imparts blue-red pigments to flowers, fruits, and red wine. Petunidin chloride binds with and suppresses the activity offocal adhesion kinase and to inh...

  • YN440213 Y15 4506-66-5

    Y15 is a small-molecule FAK scaffolding inhibitor that directly inhibits FAK autophosphorylation in a dose- and time-dependent manner.

  • YN440390 NAMI-A 201653-76-1

    NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. In vitro: NAMI-A can significantly affect tumor cells with metastatic ability. The half...

  • YN440097 PF-431396 717906-29-1

    PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.

  • YN440096 PF-562271 717907-75-0

    PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CD...

  • YN440253 NVP-TAE 226 761437-28-9

    TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

  • YN440098 PF-573228 869288-64-2

    PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.

  • YN440095 PF-562271 besylate 939791-38-5

    PF-562271 besylate is a potent ATP-competitive, reversible inhibitor ofFAK and Pyk2kinase, with an IC50 of 1.5nM and 13nM, respectively.

  • YN440298 PND-1186 1061353-68-1

    PND-1186 (VS-4718) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. Phase 1.

  • YN440200 Defactinib 1073154-85-4

    Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.

  • YN440201 Defactinib hydrochloride 1073160-26-5

    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novelFAKinhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

  • YN440016 GSK2256098 1224887-10-8

    GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM.

  • YN440119 Conteltinib 1384860-29-0

    Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect onFAKwith an IC50 of 1.6nM.

  • YN440200 Defactinib

    Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.


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