Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence ofHIVinfection.
Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with highanti-HIVactivity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry .
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitiveS-adenosyl-methionine decarboxylase (SAMDC)inhibitor tha...
Corydine is a naturally occurring alkaloid which can be extracted from plants such asCroton echinocarpusleaves. Corydine is efficient on inhibitingreverse transcriptase(RT) activity with an IC50 of 356.8 μg/mL. Corydine displays s...
Bellidifolin is a xanthone isolated from the stems ofSwertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities . Bellidifolin also acts as aviral protein R (Vpr)inhibitor.
3-Deazaadenosine is an inhibitor ofS-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIVactivity.
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potenthuman immunodeficiency virus type 1 (HIV-1)inhibitor with an EC50 of 10μM. Formycin A shows antitumor and antiviral activities.
Dextran sulfate sodium salt (...
Dextran sulfate sodium salt (MW 4500-5500) is a is a polymer of anhydroglucose with the molecular weight range of 4500-5500. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adso...
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
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