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FKBP

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN330058 Rapamycin 53123-88-9

    Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.

  • YN330274 Tacrolimus 104987-11-3

    Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • YN330248 Ascomycin 104987-12-4

    Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

  • YN330057 Everolimus 159351-69-6

    Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.

  • YN330195 GPI-1046 186452-09-5

    GPI-1046 is a immunophilin lig and without antibiotic action and attenuates ethanol intake in part through the upregulation ofglutamate transporter 1 (GLT1)in PFC and NAc-core. GPI-1046 is an analog of FK506, which is a...

  • YN330145 SLF 195513-96-3

    SLF is a synthetic lig and forFK506-binding protein (FKBP)with an affinity of 3.1μM forFKBP51 and an IC50 of 0.22μM forFKBP12. SLF can be used in the synthesis of PROTAC .

  • YN330143 AP1867 195514-23-9

    AP1867 is a synthetic FKBP12F36V-directed lig and .

  • YN330330 Rimiducid 195514-63-7

    Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking theFKBPdomains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly inducesapoptosis.

  • YN330279 AP20187 195514-80-8

    AP20187 (B/B Homodimerizer) is a cell-permeable lig and used to dimerizeFK506-binding protein(FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

  • YN330059 Rapamycin-d3 392711-19-2

    Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric ...

  • YN330187 SKF1 678997-25-6

    SKF1 is aFK506suppressor, causes a mitochondrially induced death in low salt, concomitant with the release ofreactive oxygen species (ROS).

  • YN330115 Shield-1 914805-33-7

    Shield-1 is a specific, cell-permeant and high-affinity lig and of FK506-binding protein-12 (FKBP), and reverses the instability by binding tomutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused pro...

  • YN330084 SLF-amido-C2-COOH 1092369-24-8

    SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic lig and forFKBP(SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs.

  • YN330054 SAFit1 1643125-32-9

    SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3nM.

  • YN330055 SAFit2 1643125-33-0

    SAFit2 is a highly potent, highly selectiveFK506-binding protein 51(FKBP51) inhibitor with a Ki of 6nM and also enhancesAKT2-AS160binding.

  • YN330203 Zapalog 1708091-24-0

    Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with theFK...

  • YN330063 dFKBP-1 1799711-22-0

    dFKBP-1 is a potent and PROTAC-basedFKBP12degrader. dFKBP-1 incorporates the lig and SLF (HY-114872) ofFKBP12, the Thalidomide basedcereblonlig and and a linker.

  • YN330190 FKBP12 PROTAC dTAG... 2064175-32-0

    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader ofFKBP12F36Vwith expression of FKBP12F36Vin-frame with a protein of interest. FKBP12...

  • YN330142 FKBP12 PROTAC dTAG... 2064175-41-1

    FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader. FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader ofFKBP12F36Vwith expression of FKBP12F36Vin-frame with a protein ...

  • YN330247 PROTAC FKBP Degrade... 2079056-43-0

    PROTAC FKBP Degrader-3 is a PROTAC that comprises aFKBPlig and binding group, a linker and anVHLbinding group. PROTAC FKBP Degrader-3 is a potentFKBPdegrader.

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