Chemical structure
Cat.No.
Product Name
CAS no.
Target
Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.
YN330274 Tacrolimus 104987-11-3
Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.
YN330248 Ascomycin 104987-12-4
Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
YN330057 Everolimus 159351-69-6
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.
GPI-1046 is a immunophilin lig and without antibiotic action and attenuates ethanol intake in part through the upregulation ofglutamate transporter 1 (GLT1)in PFC and NAc-core. GPI-1046 is an analog of FK506, which is a...
SLF is a synthetic lig and forFK506-binding protein (FKBP)with an affinity of 3.1μM forFKBP51 and an IC50 of 0.22μM forFKBP12. SLF can be used in the synthesis of PROTAC .
AP1867 is a synthetic FKBP12F36V-directed lig and .
YN330330 Rimiducid 195514-63-7
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking theFKBPdomains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly inducesapoptosis.
AP20187 (B/B Homodimerizer) is a cell-permeable lig and used to dimerizeFK506-binding protein(FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
YN330059 Rapamycin-d3 392711-19-2
Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric ...
SKF1 is aFK506suppressor, causes a mitochondrially induced death in low salt, concomitant with the release ofreactive oxygen species (ROS).
Shield-1 is a specific, cell-permeant and high-affinity lig and of FK506-binding protein-12 (FKBP), and reverses the instability by binding tomutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused pro...
YN330084 SLF-amido-C2-COOH 1092369-24-8
SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic lig and forFKBP(SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs.
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3nM.
SAFit2 is a highly potent, highly selectiveFK506-binding protein 51(FKBP51) inhibitor with a Ki of 6nM and also enhancesAKT2-AS160binding.
Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with theFK...
dFKBP-1 is a potent and PROTAC-basedFKBP12degrader. dFKBP-1 incorporates the lig and SLF (HY-114872) ofFKBP12, the Thalidomide basedcereblonlig and and a linker.
YN330190 FKBP12 PROTAC dTAG... 2064175-32-0
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader ofFKBP12F36Vwith expression of FKBP12F36Vin-frame with a protein of interest. FKBP12...
YN330142 FKBP12 PROTAC dTAG... 2064175-41-1
FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader. FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader ofFKBP12F36Vwith expression of FKBP12F36Vin-frame with a protein ...
YN330247 PROTAC FKBP Degrade... 2079056-43-0
PROTAC FKBP Degrader-3 is a PROTAC that comprises aFKBPlig and binding group, a linker and anVHLbinding group. PROTAC FKBP Degrader-3 is a potentFKBPdegrader.
TELL : +86-020-82000279
Add:Room 519, Block F, Guangzhou International Business Incubator, No.3 Lanyue Road, Science Town, Huangpu District, Guangzhou, China.