Charantin is a steroidal saponin isolated fromMomordica charantia, and has insulin-like activity, by increasing the release of insulin and slowing down gluconeogenesis. Charantin can againstGSK-3.
CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
Kenpaullone is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 ?M.
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3.
GSK-3β inhibitor 1
GSK-3β inhibitor 1 (compound 3a) is aglycogen synthase kinase 3β (GSK-3β)inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9nM.
Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.
Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Als...
Indirubin-5-sulfonate is acyclin-dependent kinase (CDK)inhibitor, with IC50 values of 55nM, 35nM, 150nM, 300nM and 65nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respect...
CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity...
CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
5-Iodo-indirubin-3'-monoxime is a potentGSK-3β,CDK5/P25 and CDK1/cyclin Binhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25nM, respectively.
K00546 is a potentCDK1 and CDK2inhibitor with IC50s of 0.6nM and 0.5nM forCDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potentCDC2-like kinase 1 (CLK1) and CLK3inhibitor with IC50s of 8.9n...
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor ofGSK3, with an IC50 of 12nM forhuman GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for ...
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay capable of inducing neuronal differentiation and may be useful to stem cell biology.
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