YN440420 Crotonoside 1818-71-9

Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine. Crotonoside inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/...

YN440110 3-Hydroxy Midostaurin 179237-49-1

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibitsFMS-like tyrosine kinase-3 (FLT3)autophosphorylation with IC50s of approximately 132nM and 9.8μM in culture medium and plasma, respectivel...

YN440297 TCS 359 301305-73-7

TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.

YN440257 CHIR-124 405168-58-3

CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.

YN440254 Crenolanib 670220-88-9

Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for P...

YN440086 5'-Fluoroindirubinoxime 861214-33-7

5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potentFLT3inhibitor, with an IC50 of 15nM.

YN440210 Gilteritinib 1254053-43-4

Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent tha...

YN440211 Gilteritinib hemifumarate 1254053-84-3

Gilteritinib hemifumarate is a potentFLT3/AXLinhibitor with IC50 of 0.29nM/0.73nM, respectively.

YN440232 SKLB4771 1370256-78-2

SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.

YN440351 AMG 925 1401033-86-0

AMG 925 is a potent, selective, and orally availableFLT3/CDK4dual inhibitor with IC50s of 2±1nM and 3±1nM, respectively.

YN440352 AMG 925 HCl 1401034-19-2

AMG 925 HCl is a potent, selective, and orally availableFLT3/CDK4dual inhibitor with IC50s of 2±1nM and 3±1nM, respectively.

YN440373 CCT241736 1402709-93-6

CCT241736 is a potent and orally bioavailable dualFLT3 and Aurora kinaseinhibitor, which inhibits Aurora kinases (Aurora-AKd, 7.5nM,IC50, 38nM; Aurora-BKd, 48nM), FLT3 kinase (Kd, 6.2nM), and FLT3 mutants incl...

YN440144 FN-1501 1429515-59-2

FN-1501 is a potent inhibitor ofFLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.

YN440206 UNC2025 1429881-91-3

UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, KIT and Met with ...

YN440035 MRX-2843 1429882-07-4

MRX-2843 (UNC2371) is an orally active dualMERTK and FLT3tyrosine kinases inhibitor (TKI) with enzymaticIC50s of 1.3nM for MERTK and 0.64nM for FLT3, respectively.

YN440205 G-749 1457983-28-6

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.

YN440126 FF-10101 1472797-69-5

FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.

YN440278 CA-4948 1801344-14-8

Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity.

YN440024 TAK-659 hydrochloride 1952251-28-3

TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.

YN440207 UNC2025 hydrochloride 2070015-17-5

UNC2025 hydrochloride is a potent and highly orally activeMer/Flt3inhibitor with IC50 values of 0.74nM and 0.8nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC50= 122nM;K...