Esculetin is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).
α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation ofPI3K/Aktsignaling. α-Linolenic acid possess...
Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allostericcasein kinase IIinhibitor with an IC50 of 0.74μM. Hematein inhibitsAkt/PKB Ser129phosphorylation, theWnt/TCFpathway and increasesapo...
Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicineBuxus microphylla. Cyclovirobuxine D inducesautophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits ...
Triciribine is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively does not inhibit PI3K/PDK1 5000-fold less act...
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plantCommiphora mukul, inhibits the growth of human prostate cancer cells by causingapoptosis. Z-guggulsterone inhibits angiogenesis by suppressing theVEGF–VEGF-R2–...
Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
Glaucocalyxin A, an ent-kauranoid diterpene fromRabdosia japonicavar., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulatingPI3K/Aktsignaling pathway. Glaucocalyx...
Hederacolchiside A1, isolated fromPulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulatingPI3K/Akt/mTORsignaling pathway. Hederacolchiside A1 hasantischistosomalactivity, affecting ...
Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A in...
Sophocarpine and matrine exert anti-cachectic effects probably through inhibition of TNF-alpha and IL-6 and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice.
Sophocarpine injection (called the Kangke inj...
Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate forAkt.
SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
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