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Chemical structure


Product Name

CAS no.


  • YN420294 Esculetin 305-01-1

    Esculetin is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).

  • YN420297 α-Linolenic acid 463-40-1

    α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation ofPI3K/Aktsignaling. α-Linolenic acid possess...

  • YN420099 Hematein 475-25-2

    Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allostericcasein kinase IIinhibitor with an IC50 of 0.74μM. Hematein inhibitsAkt/PKB Ser129phosphorylation, theWnt/TCFpathway and increasesapo...

  • YN420165 Deguelin 522-17-8

    Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.

  • YN420290 Cyclovirobuxine D 860-79-7

    Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicineBuxus microphylla. Cyclovirobuxine D inducesautophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits ...

  • YN420288 Sophocarpine 6483-15-4

    Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

  • YN420305 Crebanine 25127-29-1

    NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line

  • YN420243 3CAI 28755-03-5

    3CAI is a potent and specificAKT1 and AKT2inhibitor.

  • YN420215 Triciribine 35943-35-2

    Triciribine is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively does not inhibit PI3K/PDK1 5000-fold less act...

  • YN420069 (Z)-Guggulsterone 39025-23-5

    Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plantCommiphora mukul, inhibits the growth of human prostate cancer cells by causingapoptosis. Z-guggulsterone inhibits angiogenesis by suppressing theVEGF–VEGF-R2–...

  • YN420179 Miltefosine 58066-85-6

    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.

  • YN420282 Artemisinin 63968-64-9

    Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.

  • YN420304 Glaucocalyxin A 79498-31-0

    Glaucocalyxin A, an ent-kauranoid diterpene fromRabdosia japonicavar., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulatingPI3K/Aktsignaling pathway. Glaucocalyx...

  • YN420314 Hederacolchiside A1 106577-39-3

    Hederacolchiside A1, isolated fromPulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulatingPI3K/Akt/mTORsignaling pathway. Hederacolchiside A1 hasantischistosomalactivity, affecting ...

  • YN420302 Loureirin A 119425-89-7

    Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A in...

  • YN420239 Solenopsin 137038-57-4

    Solenopsin is an ATP-competitiveAKTinhibitor with IC50 value of 10μM .

  • YN420289 Sophocarpine monohydrate 145572-44-7

    Sophocarpine and matrine exert anti-cachectic effects probably through inhibition of TNF-alpha and IL-6 and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Sophocarpine injection (called the Kangke inj...

  • YN420278 Perifosine 157716-52-4

    Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

  • YN420321 Crosstide 171783-05-4

    Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate forAkt.

  • YN420258 SC79 305834-79-1

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.


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