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JAK

Chemical structure

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  • YN340269 Reticuline 485-19-8

    Reticuline, isolated fromLitsea cubeba, shows anti-inflammatory effects throughJAK2/STAT3 and NF-κBsignaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation level...

  • YN340270 Cucurbitacin I 2222-07-3

    Cucurbitacin I is a natural selective inhibitor of Jak2/STAT3, with potent anti-cancer activity.

  • YN340285 Coumermycin A1 4434-05-3

    Coumermycin A1 is aJAK2 signalactivator. Coumermycin A1 inhibits DNA Gyrasewhich thereby inhibits cell division in bacteria.

  • YN340278 Brevilin A 16503-32-5

    Brevilin A is a sesquiterpene lactone isolated fromCentipeda minimawith anti-tumor activity. Brevilin A is a selective inhibitor ofJAK-STATsignal pathway by attenuating the JAKs activity and blocking STAT3 signaling (I...

  • YN340207 NSC 33994 82058-16-0

    NSC 33994 (G6) is a selectiveJAK2inhibitor, with an IC50 of 60nM.

  • YN340265 Curculigoside 85643-19-2

    Curculigoside, a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effec...

  • YN340084 Protosappanin A 102036-28-2

    Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated fromCaesalpinia sappan L, suppressesJAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2...

  • YN340239 Lestaurtinib 111358-88-4

    Lestaurtinib (CEP-701;KT-5555) is a multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibitsJAK2,FLT3 and TrkAwith IC50s of 0.9, 3 and less than 25nM, respec...

  • YN340174 NSC 42834 195371-52-9

    NSC42834 is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.

  • YN340177 JANEX-1 202475-60-3

    JANEX-1 is a small molecule inhibitor of JAK3 that selectively inhibits JAK3 at an IC50 of 78 µM without altering the activity of JAK1 or JAK2, or any other protein tyrosine kinases (IC50 ≥ 350 µM).

  • YN340071 WHI-P97 211555-05-4

    WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays.

  • YN340201 LFM-A13 244240-24-2

    LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM, >100-fold selectivity over other protein kinases including JAK1, JAK2, HCK, EGFR,and IRK.

  • YN340105 ZM39923 273727-89-2

    ZM39923 is aJAK3inhibitor, with apIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10nM.

  • YN340148 JAK2-IN-6 353512-04-6

    JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selectiveJAK2inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferat...

  • YN340157 Pyridone 6 457081-03-7

    Pyridone 6 is apan-JAKinhibitor, which potently inhibits the JAK kinase family, with IC50s of 1nM forJAK2 and TYK2, 5nM forJAK3, and 15nM forJAK1, while displaying significantly weaker affinities (130nM to >10 mM...

  • YN340232 Tofacitinib 477600-75-2

    Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1.

  • YN340276 Ginsenoside Rk1 494753-69-4

    Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3signaling pathway ...

  • YN340233 Tofacitinib citrate 540737-29-9

    Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively.

  • YN340175 RGB-286638 784210-87-3

    RGB-286638 is aCDKinhibitor that inhibits the kinase activity ofcyclin T1-CDK9,cyclin B1-CDK1,cyclin E-CDK2,cyclin D1-CDK4,cyclin E-CDK3, and p35-CDK5with IC50s of 1, 2, 3, 4, 5 and 5nM, respectively; also...

  • YN340176 RGB-286638 free base 784210-88-4

    RGB-286638 is aCDKinhibitor that inhibits the kinase activity ofcyclin T1-CDK9,cyclin B1-CDK1,cyclin E-CDK2,cyclin D1-CDK4,cyclin E-CDK3, and p35-CDK5with IC50s of 1, 2, 3, 4, 5 and 5nM, respectively; also...

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