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Elastase

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN373286 Chrysophanol 8-O-glucoside 13241-28-6

    Chrysophanol 8-O-glucoside, from the roots ofRumex acetosa, shows moderateelastaseinhibition activity.

  • YN373377 Secologanoside 59472-23-0

    Secologanoside is a triterpenoid isolated fromPoraqueiba sericea, weakly inhibitselastasewith an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.

  • YN370028 Lodelaben 111149-90-7

    Lodelaben is a human neutrophilelastaseinhibitor with an IC50 and Kiof 0.5 and 1.5μM, respectively.

  • YN372438 Sivelestat 127373-66-4

    Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.

  • YN372533 FK706 144055-55-0

    FK706 is a potent, slow-binding and competitive inhibitor ofhuman neutrophil elastasewith an IC50 of 83nM and a Ki of 4.2nM. FK706 also inhibitsmouse neutrophil elastase and porcine pancreatic elastasewith IC50s of 22nM and...

  • YN372439 Sivelestat sodium 150374-95-1

    Sivelestat (EI546) sodium is a competitive inhibitor ofhuman neutrophil elastase, with an IC50 of 44nM and a Ki of 200nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress...

  • YN372670 DMP 777 157341-41-8

    DMP 777 is a potent, selective, and orally activehuman leukocyte elastase (HLE)inhibitor.

  • YN372532 ZD-0892 171964-73-1

    ZD-0892 is a selective and potent inhibitor of aneutrophil elastasewith Kis of 6.7 and 200nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

  • YN373987 ZD8321 182073-77-4

    ZD8321 is a potent inhibitor of humanNeutrophil elastase(NE) with a Ki of 13±1.7nM.

  • YN372362 GW311616 hydrochloride 197890-44-1

    GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

  • YN372361 GW311616 198062-54-3

    GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

  • YN372440 Sivelestat sodium tetrahydrat... 201677-61-4

    Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

  • YN372323 Freselestat 208848-19-5

    Freselestat (ONO-6818) is a potent and orally activeneutrophil elastaseinhibitor with a Ki of 12.2nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thromb...

  • YN372547 AE-3763 291778-77-3

    AE-3763 is a peptide-basedhuman neutrophil elastaseinhibitor with an IC50 of 29nM.

  • YN370512 BAY-678 675103-36-3

    BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase(HNE), with an IC50 of 20nM. BAY-678 is also nominated as a chemical probe to the public via the Structural ...

  • YN372322 Alvelestat 848141-11-7

    Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.

  • YN372584 BAY-85-8501 1161921-82-9

    BAY-85-8501 is a selective, reversible and potent inhibitor ofHuman Neutrophil Elastase (HNE), with an IC50 of 65 pM.

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