YN373286 Chrysophanol 8-O-glucoside 13241-28-6

Chrysophanol 8-O-glucoside, from the roots ofRumex acetosa, shows moderateelastaseinhibition activity.

YN373377 Secologanoside 59472-23-0

Secologanoside is a triterpenoid isolated fromPoraqueiba sericea, weakly inhibitselastasewith an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.

YN370028 Lodelaben 111149-90-7

Lodelaben is a human neutrophilelastaseinhibitor with an IC50 and Kiof 0.5 and 1.5μM, respectively.

YN372438 Sivelestat 127373-66-4

Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.

YN372533 FK706 144055-55-0

FK706 is a potent, slow-binding and competitive inhibitor ofhuman neutrophil elastasewith an IC50 of 83nM and a Ki of 4.2nM. FK706 also inhibitsmouse neutrophil elastase and porcine pancreatic elastasewith IC50s of 22nM and...

YN372439 Sivelestat sodium 150374-95-1

Sivelestat (EI546) sodium is a competitive inhibitor ofhuman neutrophil elastase, with an IC50 of 44nM and a Ki of 200nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress...

YN372670 DMP 777 157341-41-8

DMP 777 is a potent, selective, and orally activehuman leukocyte elastase (HLE)inhibitor.

YN372532 ZD-0892 171964-73-1

ZD-0892 is a selective and potent inhibitor of aneutrophil elastasewith Kis of 6.7 and 200nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

YN373987 ZD8321 182073-77-4

ZD8321 is a potent inhibitor of humanNeutrophil elastase(NE) with a Ki of 13±1.7nM.

YN372362 GW311616 hydrochloride 197890-44-1

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

YN372361 GW311616 198062-54-3

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

YN372440 Sivelestat sodium tetrahydrat... 201677-61-4

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

YN372323 Freselestat 208848-19-5

Freselestat (ONO-6818) is a potent and orally activeneutrophil elastaseinhibitor with a Ki of 12.2nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thromb...

YN372547 AE-3763 291778-77-3

AE-3763 is a peptide-basedhuman neutrophil elastaseinhibitor with an IC50 of 29nM.

YN370512 BAY-678 675103-36-3

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase(HNE), with an IC50 of 20nM. BAY-678 is also nominated as a chemical probe to the public via the Structural ...

YN372322 Alvelestat 848141-11-7

Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.

YN372584 BAY-85-8501 1161921-82-9

BAY-85-8501 is a selective, reversible and potent inhibitor ofHuman Neutrophil Elastase (HNE), with an IC50 of 65 pM.