Corydalmine (L-Corydalmine), an alkaloid isolated from roots ofCorydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent an...
Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.
Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
Antileukinate, a hexapeptide, is a potent inhibitor ofCXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .
ALX 40-4C is a small peptide inhibitor of thechemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also a...
Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
AMD 3465 hexahydrobromide
AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist ofCXCR4, inhibits binding of 12G5 mAb and CXCL12AF647toCXCR4, with IC50s of 0.75nM and 18nM in SupT1 cells; AMD 3465 also po...
AMD 3465 (GENZ-644494) is a potent antagonist ofCXCR4, inhibits binding of 12G5 mAb and CXCL12AF647toCXCR4, with IC50s of 0.75nM and 18nM in SupT1 cells; AMD 3465 also potently inhibits the replication of...
SB-265610 is a selective, competitive, nonpeptide and allostericCXCR2antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC50s...
Reparixin(Repertaxin) is a inhibitor of human CXCR1/R2 and rat CXCR2 receptor activation. It also inhibits human CXCL8 receptor activation.
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively...
SCH-527123 is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
SCH 563705 is a potent and orally availableCXCR2 and CXCR1antagonist, with IC50s of 1.3nM, 7.3nM and Kis of 1 and 3nM, respectively.
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