Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR...
Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free ...
OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.
Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kin...
GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.
PLX647 is an orally active, highly specific dualFMS and KITkinase inhibitor, with IC50s of 28 and 16nM, respectively. PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1μM ...
PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49nM, it is also aChk2inhibitor, with a Ki of 47nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2,Fms,...
BLZ945 is a potent, selective and brain-penetrantCSF-1R (c-Fms)inhibitor with an IC50 of 1nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs.
Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Phase 3.
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally activecolony-stimulating factor-1 receptor (CSF-1R)inhibitor with an IC50 of 3.2nM. Edicotinib exhibits less inhibitory effects on KIT and FLT...
PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
ARRY-382 is a potent, oral and highly selective inhibitor ofCSF1R/c-Fmswith an IC50 of 9nM. ARRY-382 can be used for the research of advanced or metastatic cancers.
DCC-3014 is ac-FMS(CSF-IR) and c-Kitdual inhibitor extracted from patent WO2014145025A2, Compound Example 10, hasIC50s of <0.01μM and 0.1-1μM, respectively.
PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitivecolony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kitinhibitor, with IC50s of 20 and 10nM, resp...
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