Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibitspoly(ADP-ribose) polymerase (PARP-1)activity in vitro.
4'-Methoxychalcone regulates adipocyte differentiation throughPPARγactivation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
INO-1001 is a potent inhibitor of PARP with IC50 of <50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. Phase 2.
1,5-Isoquinolinediol is a potentPARPinhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina.
5,7,4'-Trimethoxyflavone is isolated fromKaempferia parviflora(KP) that is a famous medicinal plant from Thail and . 5,7,4'-Trimethoxyflavone inducesapoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin...
3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herbCorydalis yanhusuoW.T. Wang. Dehydrocorydaline regulates protein expression ofBax,Bcl-2; activatescaspase-7,caspase-8, an...
Fucosterol is isolated fromE. stoloniferawith anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation ofPPARα and C/EBPαexpression.
Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells.
Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins...
5,7-Dihydroxychromone, the extract ofCudrania tricuspidata, activatesNrf2/AREsignal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits ...
Verminoside is an iridoid isolated fromKigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associa...
Oroxin A exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels.
Oroxin A and oroxin B are xanthine ...
BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
Paris saponin VII
Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
NU1025 is a potentPARPinhibitor with an IC50 of 400nM and a Ki of 48nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity .
MN-64 is a potenttankyrase 1inhibitor, with IC50s of 6nM, 72nM, 19.1μM, and 39.4μM forTNKS1, TNKS2, ARTD1 and ARTD2, respectively.
K-756 is a direct and selectivetankyrase(TNKS) inhibitor, which inhibits the ADP-ribosylation activity ofTNKS1 and TNKS2with IC50s of 31 and 36nM, respectively.
Rucaparib (Rubraca, AG014699, PF01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.
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