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PARP

Chemical structure

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CAS no.

Target

  • YN310137 Nudifloramide 701-44-0

    Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibitspoly(ADP-ribose) polymerase (PARP-1)activity in vitro.

  • YN310190 4'-Methoxychalcone 959-23-9

    4'-Methoxychalcone regulates adipocyte differentiation throughPPARγactivation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.

  • YN290167 3-Aminobenzamide 3544-24-9

    INO-1001 is a potent inhibitor of PARP with IC50 of <50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. Phase 2.

  • YN310382 1,5-Isoquinolinediol 5154-02-9

    1,5-Isoquinolinediol is a potentPARPinhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina.

  • YN310372 5,​7,​4'-​Trimethoxyflavon... 5631-70-9

    5,7,4'-Trimethoxyflavone is isolated fromKaempferia parviflora(KP) that is a famous medicinal plant from Thail and . 5,7,4'-Trimethoxyflavone inducesapoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin...

  • YN310152 3-Methoxybenzamide 5813-86-5

    3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)

  • YN310362 Dehydrocorydaline nitrate 13005-09-9

    Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herbCorydalis yanhusuoW.T. Wang. Dehydrocorydaline regulates protein expression ofBax,Bcl-2; activatescaspase-7,caspase-8, an...

  • YN310361 Fucosterol 17605-67-3

    Fucosterol is isolated fromE. stoloniferawith anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation ofPPARα and C/EBPαexpression.

  • YN310345 Dehydrocorydaline 30045-16-0

    Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins...

  • YN310353 5,7-Dihydroxychromone 31721-94-5

    5,7-Dihydroxychromone, the extract ofCudrania tricuspidata, activatesNrf2/AREsignal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits ...

  • YN310350 Verminoside 50932-19-9

    Verminoside is an iridoid isolated fromKigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associa...

  • YN310354 Oroxin A 57396-78-8

    Oroxin A exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels. Oroxin A and oroxin B are xanthine ...

  • YN310028 BGP-15 66611-37-8

    BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.

  • YN310360 Paris saponin VII 68124-04-9

    Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

  • YN310257 NU1025 90417-38-2

    NU1025 is a potentPARPinhibitor with an IC50 of 400nM and a Ki of 48nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity .

  • YN310321 MN-64 92831-11-3

    MN-64 is a potenttankyrase 1inhibitor, with IC50s of 6nM, 72nM, 19.1μM, and 39.4μM forTNKS1, TNKS2, ARTD1 and ARTD2, respectively.

  • YN310381 K-756 130017-40-2

    K-756 is a direct and selectivetankyrase(TNKS) inhibitor, which inhibits the ADP-ribosylation activity ofTNKS1 and TNKS2with IC50s of 31 and 36nM, respectively.

  • YN310380 WD2000-012547 283172-68-9

    WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKiof 8.221.

  • YN290066 Rucaparib 283173-50-2

    Rucaparib (Rubraca, AG014699, PF01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

  • YN290168 AG14361 328543-09-5

    AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.

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