YN370340 AMP-PCP 3469-78-1

AMP-PCP is an ATP analogue and can bind toHsp90N-terminal domain with aKdvalue of 3.8μM. AMP-PCP binding favors the formation of the active homodimer ofHsp90.

YN373233 Cucurbitacin D 3877-86-9

Cucurbitacin D is an active component inCucurbita texana, disrupts interactions betweenHsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of t...

YN372856 Teprenone 6809-52-5

Teprenone, an acylic polyisoprenoid, that is known as tetraprenylacetone or geranylgeranylacetone, is an anti-ulcer drug, clinically used for gastritis.

YN370341 AMP-PCP disodium 7414-56-4

AMP-PCP disodium is an ATP analogue and can bind toHsp90N-terminal domain with aKdvalue of 3.8μM. AMP-PCP disodium binding favors the formation of the active homodimer ofHsp90.

YN371784 Tamoxifen 10540-29-1

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

YN373359 10,11-Dehydrocurvularin 21178-57-4

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of theheat shock response. 10,11-Dehydrocurvularin inhibitsTGF-β signallingpathway. Anti-tumorous activity.

YN373210 Falcarinol 21852-80-2

Falcarinol (Panaxynol) is a natural, orally activeHsp90inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) inducesapoptosis.

YN373080 Paeoniflorin 23180-57-6

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.

YN373349 Feretoside 27530-67-2

Feretoside, a phenolic compound extracted from the barks ofE. ulmoides, is aHSP inducerwhich act as cytoprotective agent.

YN372271 Geldanamycin 30562-34-6

Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

YN371028 3-Phenyltoxoflavin 32502-63-9

3-Phenyltoxoflavin, a derivative of Toxoflavin, is anHsp90inhibitor, with aKdof 585nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity.

YN371783 Tamoxifen Citrate 54965-24-1

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

YN370455 Pifithrin-μ 64984-31-2

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

YN370232 Tanespimycin 75747-14-7

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

YN371527 17-AEP-GA 75747-23-8

17-AEP-GA, anHSP90antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin.

YN372541 Rocaglamide 84573-16-0

Rocaglamide (Roc-A) is isolated from the genusAglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor ofNF-κBactivation in T-cells. Rocaglamide is a potent and se...

YN372500 ML346 100872-83-1

ML346 is an activator ofHsp70 expression and HSF-1 activity, with an EC50 of 4.6μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 ind...

YN373999 Bimoclomol 130493-03-7

Bimoclomol is aheat shock protein (HSP)coinducer, used for treatment of cardiovascular diseases.

YN372253 MKT-077 147366-41-4

MKT-077 is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.

YN371785 Tamoxifen-​d5 157698-32-3

Tamoxifen-d5 (ICI 47699-d5) is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potentHsp90activator and enhances the Hsp90 molecular ch...