YN340268 Tephrosin 76-80-2

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of ofEGFR and ErbB2by inducing internalization of the receptors.

YN340255 Khellin 82-02-0

Khellin, a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.

YN340158 Genistein 446-72-0

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50...

YN340143 Chrysophanol 481-74-3

Chrysophanic acid (Chrysophanol), a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.

YN340192 Butein 487-52-5

Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.

YN340275 Sulforaphene 592-95-0

Sulforaphene, isolated from radish seeds, exhibits an ED50against velvetleaf seedlings approximately 2 x 10-4M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibitingEGFR,p-ERK1/2,NF‐κB and ot...

YN340133 ZM 449829 4452-06-6

ZM 449829 is a potent, selective and ATP competitive inhibitor ofJAK3, with apIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of theJAK3.

YN340280 β-Hydroxyisovalerylshikonin 7415-78-3

Beta-hydroxyisovalerylshikonin is a natural product isolated fromLithospermium radix, acts as a potent inhibitor ofprotein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. B...

YN340261 Cyasterone 17086-76-9

Cyasterone, a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.

YN340125 EMI48 34564-13-1

EMI48, the derivative of EMI1, displays greater potency toward mutantEGFRthan EMI1. EMI48 inhibitsEGFRtriple mutants.

YN340281 Astragaloside VI 84687-45-6

Astragaloside VI could activateEGFR/ERKsignalling pathway to improve wound healing.

YN340022 NSC 228155 113104-25-9

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

YN340179 Tyrphostin 23 118409-57-7

AG-18 inhibits EGFR with IC50 of 35 μM.

YN340087 Tyrphostin AG30 122520-79-0

Tyrphostin AG30 (AG30) is a potent and selectiveEGFR tyrosine kinaseinhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in p...

YN340018 (E)-AG 99 122520-85-8

AG99 is a potent and selective inhibitor of EGFR.

YN340215 Lavendustin A 125697-92-9

Lavendustin A (RG-14355), isolated fromStreptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor oftyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase. It suppresses VEG...

YN340295 Lavendustin C 125697-93-0

Lavendustin C is a potentCa2+calmodulin-dependent kinase II (CaMK II)inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibitsEGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+)kinase (IC50=0.5 µM).

YN340089 AG-490 133550-30-8

AG-490 (Tyrphostin B42) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

YN340172 AG 555 133550-34-2

AG-555 is an inhibitor of tyrosine kinase , interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM.

YN340021 AG-494 133550-35-3

AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).