Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.
Physostigmine (Eserine) is a reversibleacetylcholinesterase (AChE)inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic m...
Physostigmine hemisulfate (Eserine hemisulfate) is a potentcholinesteraseinhibitor. Physostigmine hemisulfate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate induces rean...
Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC50=77nM;Ki=16nM...
Pralidoxime iodide is a reactivator ofacetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent....
Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibitedacetylcholinesterase (AChE) and reduces acute toxicity...
Edrophonium chloride is the chloride salt of edrophonium, which is a rapid-onset, short-acting, readily reversible inhibitor of acetylcholinesterase.
Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and...
Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzymeacetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.
Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disea...
Linarin (Buddleoside), isolated from the flower extract ofMentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE).
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent.
Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation.
Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.
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