YN440328 Picropodophyllin 477-47-4

Picropodophyllin (PPP) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FG...

YN440069 AG1024 65678-07-1

AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).

YN440288 PQ401 196868-63-0

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

YN440073 BMS-536924 468740-43-4

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.

YN440068 NVP-ADW742 475488-23-4

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

YN440405 NVP-AEW541 475489-16-8

NVP-AEW541 is a potent inhibitor ofIGF-1Rwith IC50 of 0.15μM, also inhibitsInsR, with IC50 of 0.14μM.

YN440383 Indirubin Derivative E804 854171-35-0

Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor(IGF1R), with an IC50 of 0.65μM for IGF1R.

YN440050 Linsitinib 867160-71-2

Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Pha...

YN440055 BMS-754807 1001350-96-4

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PK...

YN440103 GSK1904529A 1089283-49-7

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM in cell-free assays, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.

YN440280 I-OMe-Tyrphostin AG 538 1094048-77-7

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor ofIGF-1R(insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cyto...

YN440050 Linsitinib

Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Pha...