Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN440422 Formononetin 485-72-3
Formononetin is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
YN440029 PD-166866 192705-79-6
PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.
PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR,FGFR and Srcfamily activities with nanomolarIC50 values.
SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
YN440261 CP-547632 252003-65-9
CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGFkinases inhibitor with IC50s of 11nM and 9nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, a...
YN440262 CP-547632 hydrochloride 252003-71-7
CP-547632 hydrochloride is an orally active, ATP-competitive and potent VEGFR-2 and FGFkinases inhibitor with IC50s of 11nM and 9nM, respectively. CP-547632 hydrochloride is selective for VEGFR2 and bFGF ove...
YN440102 Orantinib 252916-29-3
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, ...
YN440409 Nintedanib 656247-17-5
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.
YN440140 Nintedanib esylate 656247-18-6
Nintedanib is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
SUN11602 is a small synthetic compound that mimics the neuroprotective activities of bFGF and activates key molecules in the FGF receptor-1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR...
YN440004 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2nM for KDR,Flt-1,FGFR1 and PDGFRα, respectively.
YN440333 SSR128129E 848318-25-2
SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.
YN440047 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibitsreceptor tyrosine kinases and Src kinases; hasIC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PD...
YN440049 TG 100801 867331-82-6
TG 100801 is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibitsreceptor tyrosine kinases and Src kinases; ha...
YN440265 Infigratinib 872511-34-7
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little...
R1530 is a highly potent, orally bioavailable, dual-actingmitosis/angiogenesisinhibitor, with antitumor and anti-angiogenic activity. R1530 is a multikinase inhibitor which binds to 31 kinases withKds of <500nM. R1530 inhibitsVGF...
YN440131 ENMD-2076 934353-76-1
ENMD-2076 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4nM forAurora A,Flt3,KDR/VEGFR2,Flt4/VEGFR3,FGFR1,FGFR2,Src,PDGFRα, respectively.
EOC317 (ACTB-1003) is an oral kinase inhibitor with IC50s of 6, 2 and 4nM forFGFR1,VEGFR2 and Tie-2.
AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, C...
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