7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous lig and of the orphan GPCR receptorEBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 p...
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6nM.
ML401, a potent chemical probe, selectively antagonizesEBI2(also known asGPR183) with an IC50 of 1.03nM. ML401 displays activity in a chemotaxis assay (IC50=6.24nM). ML401 shows good stability and no toxicity.
NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16nM(Binding) and 11nM (Functional).
NIBR189 is a potent and selective EBI2 antagonist with im...
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