YN321725 Deoxycholic acid 83-44-3

Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity.

YN321714 Hyodeoxycholic acid 83-49-8

Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

YN321726 Deoxycholic acid sodium salt 302-95-4

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brow...

YN321541 Triamterene 396-01-0

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

YN320215 SB756050 447410-57-3

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).

YN320442 SBI-115 882366-16-7

SBI-115 is aTGR5 (GPCR19)antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

YN320594 INT-767 1000403-03-1

INT-767 is a dualfarnesoid X receptor (FXR)/TGR5agonist with meanEC50s of 30 and 630nM, respectively.

YN320837 TGR5 Receptor Agonist 1197300-24-5

TGR5 Receptor Agonist (CCDC), a potentTGR5(GPCR19)agonist, shows improved potency in the U2-OS cell assay (pEC50=6.8) and in melanophore cells (pEC50=7.5).

YN321014 INT-777 R-enantiomer 1198786-98-9

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50of 4.79μM for TGR5, and less potent than INT-777.

YN321013 INT-777 1199796-29-6

INT-777 is a potentTGR5agonist with an EC50 of 0.82μM.

YN320409 TC-G 1005 1415407-60-1

TC-G 1005 is a potent, selective and orally active agonist of theBA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucos...

YN320122 BAR502 1612191-86-2

BAR502 is a dualFXR and GPBAR1agonist with IC50 values of 2μM and 0.4μM, respectively.

YN320123 BAR501 1632118-69-4

BAR501 is a potent and selective agonist ofGPBAR1with an EC50 of 1μM.