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Beta-secretase

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN380241 Scoulerine 6451-73-6

    Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potentantimitoticcompound. Scoulerine is also an inhibitor ofBACE1(ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cyc...

  • YN380259 Glabrolide 10401-33-9

    Glabrolide, derived fromGlycyrrhiza uralensisFisch., is a β-secretase 1 (BACE-1) inhibitor.

  • YN380228 Aloenin 38412-46-3

    Aloenin (Aloenin A) is a class of anthraquinones isolated fromAloearborescens. Aloenin has potent peroxyl radical-scavenging activities and moderate inhibitory active onβ-secretase (BACE).

  • YN380034 Kushenol C 99119-73-0

    Kushenol C, isolated from the roots ofSophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibitsBACE1 (β-site APP cleaving enzyme 1)with an IC50 of 5.45 µM.

  • YN380248 Aloeresin D 105317-67-7

    Aloeresin D is a chromone glycoside isolated fromAloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39μM.

  • YN380026 LY2811376 1194044-20-6

    LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 ...

  • YN380035 Atabecestat 1200493-78-2

    Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally activeβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tole...

  • YN380078 AZD3839 free base 1227163-84-9

    AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.

  • YN380075 LY2886721 1262036-50-9

    LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.

  • YN380117 Verubecestat 1286770-55-5

    Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.

  • YN380011 Lanabecestat 1383982-64-6

    Lanabecestat(AZD3293, LY3314814)is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki?of?0.4 nM.

  • YN380012 (1α,1'S,4β)-Lanabecestat 1384082-96-5

    (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is aBeta site APP Cleaving Enzymel (BACE1)inhibitor extracted from patent WO2012087237A1, compound 20a, hasIC50s of 2.2nM (TR-FRET assay) and 0.28nM (sAPPp...

  • YN380036 Elenbecestat 1388651-30-6

    Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrantBACE-1inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.

  • YN380047 PF-06751979 1818339-66-0

    PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3nM in BACE1 binding assay.

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