Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potentantimitoticcompound. Scoulerine is also an inhibitor ofBACE1(ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cyc...
Aloenin (Aloenin A) is a class of anthraquinones isolated fromAloearborescens. Aloenin has potent peroxyl radical-scavenging activities and moderate inhibitory active onβ-secretase (BACE).
Kushenol C, isolated from the roots ofSophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibitsBACE1 (β-site APP cleaving enzyme 1)with an IC50 of 5.45 µM.
Aloeresin D is a chromone glycoside isolated fromAloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39μM.
LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 ...
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally activeβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tole...
Lanabecestat（AZD3293, LY3314814）is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki?of?0.4 nM.
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is aBeta site APP Cleaving Enzymel (BACE1)inhibitor extracted from patent WO2012087237A1, compound 20a, hasIC50s of 2.2nM (TR-FRET assay) and 0.28nM (sAPPp...
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrantBACE-1inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3nM in BACE1 binding assay.
TELL : +86-020-31703347
Add:Room 519, Block F, Guangzhou International Business Incubator, No.3 Lanyue Road, Science Town, Huangpu District, Guangzhou, China.
ULS products are chemical reagents for Research Use Only！Copyright © 2020-2021 ULS. All Rights Reserved.