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GPR40

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN321599 Vincamine 1617-90-9

    Vincamine, an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.

  • YN321283 GW-1100 306974-70-9

    GW-1100 is a selectiveGPR40antagonist with apIC50 of 6.9. GW1100 acts as a GPR40 inverse agonist.

  • YN320206 DC260126 346692-04-4

    DC260126 is a potent antagonist ofGPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58μM...

  • YN321010 GW9508 885101-89-3

    GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.

  • YN320274 Fasiglifam 1000413-72-8

    Fasiglifam (TAK-875) is a potent, selective and orally bioavailableGPR40agonist withEC50of 72nM.

  • YN320615 AM-4668 1011531-27-3

    AM-4668 is aGPR40agonist for type 2 diabetes.EC50s of 3.6nM and 36nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.

  • YN320859 TUG-424 1082058-99-8

    TUG-424 is a potent and selectivefree fatty acid receptor 1 (FFA1/GPR40)agonist with an EC50 of 32nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100nM. TUG-424 may serve to explore the role ...

  • YN320739 AM-1638 1142214-62-7

    AM-1638 is a potent and orally bioavailableGPR40/FFA1full agonist with an EC50 of 0.16μM.

  • YN320079 Setogepram sodium salt 1254472-97-3

    Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sod...

  • YN320815 AMG 837 calcium hydrate 1259389-38-2

    AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

  • YN320626 GPR40 Activator 2 1312787-30-6

    GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.

  • YN321016 TUG-770 1402601-82-4

    TUG-770 is a potent, selective and orally activeGPR40/FFA1agonist with an EC50 of 6nM forhuman FFA1. TUG-770 shows a high selectivity forFFA1over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, ...

  • YN321248 LY2922470 1423018-12-5

    LY2922470 is a potent, selective and orally available agonist of theG protein-coupled receptor 40 (GPR40), with EC50s of 7nM, 1nM and 3nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduce...

  • YN320228 GPR40 agonist 4 2102196-57-4

    GPR40 agonist 4 is a potentfree fatty acid receptor 1(FFA1/ GPR40) agonist with apEC50of 7.54.

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