Vincamine, an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.
DC260126 is a potent antagonist ofGPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58μM...
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.
AM-4668 is aGPR40agonist for type 2 diabetes.EC50s of 3.6nM and 36nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.
TUG-424 is a potent and selectivefree fatty acid receptor 1 (FFA1/GPR40)agonist with an EC50 of 32nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100nM. TUG-424 may serve to explore the role ...
Setogepram sodium salt
Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sod...
AMG 837 calcium hydrate
AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
TUG-770 is a potent, selective and orally activeGPR40/FFA1agonist with an EC50 of 6nM forhuman FFA1. TUG-770 shows a high selectivity forFFA1over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, ...
LY2922470 is a potent, selective and orally available agonist of theG protein-coupled receptor 40 (GPR40), with EC50s of 7nM, 1nM and 3nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduce...
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