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5-HT Receptor

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN320091 Cinanserin hydrochloride 54-84-2

    Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptorantagonist with a Ki of 41nM. Cinanserin hydrochloride has a much higher binding affinity for the5-HT2than for the 5-HT1receptor (Ki...

  • YN321345 Perphenazine 58-39-9

    Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

  • YN321676 Levomepromazine 60-99-1

    Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter recept...

  • YN321485 Chlorpromazine hydrochloride 69-09-0

    Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

  • YN320129 Phenylbiguanide 102-02-3

    Phenylbiguanide is a5-HT3receptorselective agonist with an EC50 of 3.0±0.1μM.

  • YN321589 Thioridazine hydrochloride 130-61-0

    Thioridazine is a potent antianxiety and antipsychotic agent.

  • YN321657 Serotonin hydrochloride 153-98-0

    Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

  • YN321609 Pimethixene 314-03-4

    Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4as well as muscari...

  • YN321728 Harmine hydrochloride 343-27-1

    Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value ...

  • YN321729 Harmine 442-51-3

    Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but n...

  • YN321705 Nuciferine 475-83-2

    Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.

  • YN321707 Rotundine 483-14-7

    Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

  • YN321732 Jatrorrhizine hydroxide 483-43-2

    Jatrorrhizine hydroxide is an alkaloid isolated fromCoptis chinensiswith neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor ofAChE(IC50=872...

  • YN320094 Spiramide 510-74-7

    Spiramide (AMI-193) is a potent and selective antagonist of5-HT2 and dopamine D2 receptor, with Kis of 2nM and 3nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2versus5-HT1C(Ki=4300nM) receptors. Spiramid...

  • YN321629 Trimipramine maleate 521-78-8

    Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.

  • YN321524 Amitriptyline hydrochloride 549-18-8

    Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

  • YN321751 Myristicin 607-91-0

    Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.

  • YN321463 Cyproheptadine hydrochloride 969-33-5

    Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6nM. Cyproheptadine hydrochloride is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, an...

  • YN320075 Pipamperone 1893-33-0

    Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor(pKi=8.2) and D4receptor(pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).

  • YN321127 Loxapine 1977-10-2

    Loxapine (Adasuve), a typical neuroleptic, is a drug with D2/D3 receptor antagonist activity and a higher affinity for D3 than D2. Loxapine displays an extremely strong binding affinity for dopamine D4 and serotonin...

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