YN320091 Cinanserin hydrochloride 54-84-2

Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptorantagonist with a Ki of 41nM. Cinanserin hydrochloride has a much higher binding affinity for the5-HT2than for the 5-HT1receptor (Ki...

YN321345 Perphenazine 58-39-9

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

YN321676 Levomepromazine 60-99-1

Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter recept...

YN321485 Chlorpromazine hydrochloride 69-09-0

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

YN320129 Phenylbiguanide 102-02-3

Phenylbiguanide is a5-HT3receptorselective agonist with an EC50 of 3.0±0.1μM.

YN321589 Thioridazine hydrochloride 130-61-0

Thioridazine is a potent antianxiety and antipsychotic agent.

YN321657 Serotonin hydrochloride 153-98-0

Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

YN321609 Pimethixene 314-03-4

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4as well as muscari...

YN321728 Harmine hydrochloride 343-27-1

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value ...

YN321729 Harmine 442-51-3

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but n...

YN321705 Nuciferine 475-83-2

Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.

YN321707 Rotundine 483-14-7

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

YN321732 Jatrorrhizine hydroxide 483-43-2

Jatrorrhizine hydroxide is an alkaloid isolated fromCoptis chinensiswith neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor ofAChE(IC50=872...

YN320094 Spiramide 510-74-7

Spiramide (AMI-193) is a potent and selective antagonist of5-HT2 and dopamine D2 receptor, with Kis of 2nM and 3nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2versus5-HT1C(Ki=4300nM) receptors. Spiramid...

YN321629 Trimipramine maleate 521-78-8

Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.

YN321524 Amitriptyline hydrochloride 549-18-8

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

YN321751 Myristicin 607-91-0

Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.

YN321463 Cyproheptadine hydrochloride 969-33-5

Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6nM. Cyproheptadine hydrochloride is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, an...

YN320075 Pipamperone 1893-33-0

Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor(pKi=8.2) and D4receptor(pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).

YN321127 Loxapine 1977-10-2

Loxapine (Adasuve), a typical neuroleptic, is a drug with D2/D3 receptor antagonist activity and a higher affinity for D3 than D2. Loxapine displays an extremely strong binding affinity for dopamine D4 and serotonin...