Isoeuphorbetin, a dimeric coumarin isolated fromViola philippica, is a potentHCV proteaseinhibitor with an IC50 of 3.63 µg/mL.
Boceprevir is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1.
Asunaprevir is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.
Danoprevir(ITMN-191) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.
Simeprevir (TMC435) is an oral and potentHCV NS3/4A proteaseinhibitor with a Ki of 0.36nM, and inhibits HCV replication with an EC50 of 7.8nM.
Grazoprevir potassium salt
Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor ofHepatitis C virus NS3/4aprotease with broad activity across genotypes and resistant variants, with Kis of 0.01nM (gt1b), 0.01nM (gt1a), 0.08nM (gt2a...
Grazoprevir anhydrous is a Hepatitis C Virus NS3/4A Protease inhibitor with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively.
Glecaprevir is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication. It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV geno...
Grazoprevir sodium salt
Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor ofHepatitis C virus NS3/4aprotease with broad activity across genotypes and resistant variants, with Kis of 0.01nM (gt1b), 0.01nM (gt1a), 0.08nM (gt2a), 0.1...
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