L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidylgrowth hormone secretagogue (GHS)agonist. L-692429 binds toG protein-coupled receptor with a Ki of 63nM.
L-692585 is a potent and nonpeptidylgrowth hormone secretagogue receptor (GHS-R1a)agonist, with a Ki of 0.8nM. L-692585 acts directly on somatotropes causing GH release.
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR)agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.
Capromorelin Tartrate (CP 424391-18), a member of the growth hormone secretagogue (GHS) class of drugs, is a ghrelin receptor agonist and a novel therapy for stimulation of appetite in dogs with Ki of 7 nM for hGHS...
Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay.
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous lig and of G-pr...
TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9nM/5nM in the presence of Zn2+, and 280nM/180nM in the absence of Zn2+forhuman/murine GPR39.
TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist withEC50values of 0.4 and 0.8nM for rat and human receptors respectively.
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