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Endothelin Receptor

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN321451 Sulfisoxazole 127-69-5

    Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent.

  • YN321256 Aminaftone 14748-94-8

    Aminaftone, a derivative of 4-aminobenzoic acid, downregulatesendothelin-1(ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.

  • YN321879 Atrial Natriuretic Peptide ... 88898-17-3

    Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulatedendothelin-1secretion in a concentration-dependent manner.

  • YN321877 Carperitide 89213-87-6

    a peptide hormone that promotes the loss of fluid and electrolytes and the reduction of vascular tone.

  • YN321807 Endothelin 1 (swine, human) 117399-94-7

    Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

  • YN321851 Sarafotoxin S6a 126738-34-9

    Sarafotoxin S6a, a sarafotoxin analogue, is aendothelin receptoragonist  and has anETA/ETBselectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value o...

  • YN320582 BQ-123 136553-81-6

    BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

  • YN321062 IRL-1620 142569-99-1

    IRL-1620 is a potent and selectiveendothelin receptor type B (ETB)agonist with a Ki of 16 pM.

  • YN321323 Bosentan 147536-97-8

    Bosentan is a competitive and dual antagonist ofendothelin-1 (ET)for the ETA and ETBreceptors with Kiof 4.7nM and 95nM in human SMC, respectively.

  • YN321228 Ro 46-2005 150725-87-4

    Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220nM.

  • YN321046 BQ-788 sodium salt 156161-89-6

    BQ-788 sodium salt is a potent and selectiveETB receptorantagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2nM in human Girrardi heart cells.

  • YN321324 Bosentan (hydrate) 157212-55-0

    Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

  • YN320263 IRL 2500 169545-27-1

    IRL 2500 is a potentEndothelin receptorantagonist. IRL 2500 showsIC50 values of 1.3 and 94nM for ETB and ETAreceptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascu...

  • YN320976 Darusentan 171714-84-4

    Darusentan (Lu-135252) is a selectiveendothelin receptor A(ET-A)receptorantagonist, which binds with a Ki of 1.4nM to the ET-A receptor and a Kiof 184nM to ET-B receptor, respectively with a 100-fold selectivity for ETA...

  • YN321047 BQ-788 173326-37-9

    BQ-788 is a potent, selectiveETB receptorantagonist with IC50 of 1.2nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC c...

  • YN320974 Atrasentan 173937-91-2

    Atrasentan (ABT-627) is anendothelin receptorantagonist with IC50 of 0.0551nM for ETA.

  • YN320706 Ambrisentan 177036-94-1

    Ambrisentan is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).

  • YN320157 PD-159020 177904-00-6

    PD-159020 is a non-selectiveETA/ETBantagonist, with IC50s of 30 and 50nM for hETA and hETB, respectively.

  • YN321118 Tezosentan 180384-57-0

    Tezosentan (RO 610612) is anendothelin (ET)receptor antagonist, withpA2sof 9.5, 7.7 for ETA and ETBreceptors, respectively.

  • YN321306 Sitaxsentan 184036-34-8

    Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.

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