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IKK

Chemical structure

Cat.No.

Product Name

CAS no.

Target

  • YN410006 IMD-0354 978-62-1

    IMD-0354 (IKK2 Inhibitor V) is a selectiveIKKβinhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM.

  • YN410087 Malachite green oxalate 2437-29-8

    Malachite green is a synthetic dyestuff and antimicrobial with potential carcinogenicity.

  • YN410051 BAY 11-7082 19542-67-7

    BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

  • YN410084 Amlexanox 68302-57-8

    Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.

  • YN410022 INH14 200134-22-1

    INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.

  • YN410056 SC-514 354812-17-2

    SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

  • YN410041 ACHP Hydrochloride 406209-26-5

    ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selectiveIKK-βinhibitor with an IC50 of 8.5nM.

  • YN410058 IKK-IN-1 406211-06-1

    IKK-IN-1 is an inhibitor ofIKKextracted from patent WO2002024679A1, compound example 18-13.

  • YN410075 PS-1145 431898-65-6

    PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

  • YN410012 IMD-0560 439144-66-8

    IMD-0560 is a novelIκB kinase βinhibitor.

  • YN410011 BMS-345541 445430-58-0

    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.

  • YN410010 BMS-345541 hydrochloride 547757-23-3

    BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits ofIKK(IKK-2IC50=0.3μM,IKK-1IC50=4μM). BMS-345541 binds at an allosteric site of IKK.

  • YN410082 Bay 65-1942 hydrochloride 600734-06-3

    Bay 65-1942 hydrochloride is an ATP-competitive and selectiveIKKβinhibitor.

  • YN410009 BX795 702675-74-9

    BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selec...

  • YN410067 MLN120B 783348-36-7

    MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor ofIKKβwith an IC50 of 60nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rh...

  • YN410065 GSK319347A 862812-98-4

    GSK319347A is a dual inhibitor of TBK1 and IKKεwith IC50s of 93nM and 469nM, respectively. GSK319347A also inhibitsIKK2with an IC50 of 790nM.

  • YN410054 IKK 16 873225-46-8

    IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

  • YN410085 LY2409881 trihydrochloride 946518-60-1

    LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30nM.

  • YN410039 BI605906 960293-88-3

    BI605906 is a novelIKKβinhibitor with an IC50 value of 380nM when assayed at 0.1 mM ATP.

  • YN410038 MRT67307 1190378-57-4

    MRT67307 is a dual inhibitor of theIKKε and TBK-1with IC50s of 160 and 19nM, respectively. MRT67307 also inhibitsULK1 and ULK2with IC50s of 45 and 38nM, respectively. MRT67307 also blocksautophagyin cells.

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