IMD-0354 (IKK2 Inhibitor V) is a selectiveIKKβinhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM.
BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.
SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.
BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selec...
MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor ofIKKβwith an IC50 of 60nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rh...
GSK319347A is a dual inhibitor of TBK1 and IKKεwith IC50s of 93nM and 469nM, respectively. GSK319347A also inhibitsIKK2with an IC50 of 790nM.
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.
MRT67307 is a dual inhibitor of theIKKε and TBK-1with IC50s of 160 and 19nM, respectively. MRT67307 also inhibitsULK1 and ULK2with IC50s of 45 and 38nM, respectively. MRT67307 also blocksautophagyin cells.
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