Valpromide is an antiepileptic drug, derivative of Valproic acid (VPA), used as a mood-stabilizer in bipolar disorder.
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selectivesoluble epoxide hydrolase (sEH)inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxy...
CUDA is a potent inhibitor ofsoluble epoxide hydrolase (sEH), with IC50s of 11.1nM and 112nM for mouse sEH and human sEH, respectively. CUDA selectively increasesperoxisome proliferator-activated receptor (PPAR) al...
AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expressio...
trans-AUCB (t-AUCB) is a potent, orally active and selectivesoluble epoxide hydrolase (sEH)inhibitor with IC50s of 1.3nM, 8nM, 8nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activi...
AR9281 is a potent and selective inhibitor ofsoluble epoxide hydrolase (s-EH), with potential for the treatment of hypertension and type 2 diabetes.
BI-1935 is a potentsoluble epoxide hydrolase (sEH)inhibitor for diseases related to cardiovascular disease.
GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and muri...
TTPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7nM for monkey and human sEH, respectively.
EC5026 (BPN-19186) is a first-in-class, non-opioid and orally activesoluble Epoxide Hydrolase (sEH)inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain.
SWE101 (compound 22 b) is a potentsoluble epoxide hydrolase (sEH)-Pinhibitor with IC50s of 4μM and 2.8μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the ...
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