7,4'-Dihydroxyflavone
Cat. No. :YN321757
CAS No. :2196-14-7
86-020-82000279
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order@ubiochem.com| Product Name: | 7,4'-Dihydroxyflavone |
| CAS NO.: | 2196-14-7 |
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| Molecular Weight: | 254.24 |
| Molecular Formula: | C₁₅H₁₀O₄ |
| SMILES: | O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated fromGlycyrrhiza uralensis, theeotaxin/CCL11inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibitsMUC5ACgene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM. |
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