APX-115 free base
Cat. No. :YN370907
CAS No. :1270084-92-8
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order@ubiochem.com| Product Name: | APX-115 free base |
| CAS NO.: | 1270084-92-8 |
| Chemical Name: | |
| Synonyms: | Ewha-18278 free base |
| Molecular Weight: | 279.34 |
| Molecular Formula: | C₁₇H₁₇N₃O |
| SMILES: | OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney. |
| IC50&Target: | |
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