BI-671800
Cat. No. :YN320474
CAS No. :1093108-50-9
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order@ubiochem.com| Product Name: | BI-671800 |
| CAS NO.: | 1093108-50-9 |
| Chemical Name: | |
| Synonyms: | AP-761, Cmpd A |
| Molecular Weight: | 501.50 |
| Molecular Formula: | C₂₅H₂₆F₃N₅O₃ |
| SMILES: | O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C(C(F)(F)F)C=C3)=O)C=C2)N=C1N(C)C |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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