Bavisant dihydrochloride hydrate
Cat. No. :YN320925
CAS No. :1103522-80-0
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order@ubiochem.com| Product Name: | Bavisant dihydrochloride hydrate |
| CAS NO.: | 1103522-80-0 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 420.37 |
| Molecular Formula: | C₁₉H₃₁Cl₂N₃O₃ |
| SMILES: | O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4.[H]Cl.[H]Cl.O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. in vitro: Bavisant completed a phase II ADHD trial, but no results have been reported . in vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1 mg/day, 3 mg/day and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo (p=0.161), and hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed . Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. Phase 2 |
| IC50&Target: | |
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| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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