Vercirnon sodium
Cat. No. :YN321025
CAS No. :886214-18-2
86-020-82000279
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order@ubiochem.com| Product Name: | Vercirnon sodium |
| CAS NO.: | 886214-18-2 |
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| Molecular Weight: | 466.91 |
| Molecular Formula: | C₂₂H₂₀ClN₂NaO₄S |
| SMILES: | O=S(C1=CC=C(C(C)(C)C)C=C1)([N-]C2=CC=C(Cl)C=C2C(C3=CC=[N+]([O-])C=C3)=O)=O.[Na+] |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist ofCCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6nM, respectively. |
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