SB-334867
Cat. No. :YN320389
CAS No. :249889-64-3
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order@ubiochem.com| Product Name: | SB-334867 |
| CAS NO.: | 249889-64-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 355.78 |
| Molecular Formula: | C₁₇H₁₄ClN₅O₂ |
| SMILES: | O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43.Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeableorexin-1 (OX1) receptorantagonist, shows selectivity overOX2(pKb=7.4), 100-fold over 5-HT2B, 5-HT2Cwith pKi values. of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo . |
| IC50&Target: | |
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| References: |
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