Flavopiridol Hydrochloride
Cat. No. :YN250008
CAS No. :131740-09-5
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order@ubiochem.com| Product Name: | Flavopiridol Hydrochloride |
| CAS NO.: | 131740-09-5 |
| Chemical Name: | |
| Synonyms: | NSC 649890 HCl |
| Molecular Weight: | 438.30 |
| Molecular Formula: | C₂₁H₂₁Cl₂NO₅ |
| SMILES: | O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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