5-(N,N-Hexamethylene)-amiloride
Cat. No. :YN360380
CAS No. :1428-95-1
86-020-82000279
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order@ubiochem.com| Product Name: | 5-(N,N-Hexamethylene)-amiloride |
| CAS NO.: | 1428-95-1 |
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| Molecular Weight: | 311.77 |
| Molecular Formula: | C₁₂H₁₈ClN₇O |
| SMILES: | O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potentNa+/H+exchangerinhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of theHIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91μM and 1.34μM, respectively. |
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