Ribocil
Cat. No. :YN250803
CAS No. :1381289-58-2
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order@ubiochem.com| Product Name: | Ribocil |
| CAS NO.: | 1381289-58-2 |
| Chemical Name: | |
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| Molecular Weight: | 382.48 |
| Molecular Formula: | C₁₉H₂₂N₆OS |
| SMILES: | C1(C=C(NC(=N1)C1CN(CC2C=NC(NC)=NC=2)CCC1)C1=CC=CS1)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3μM. in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural lig and to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13μM versus IC50 > 26μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6nM versus Kd ≥ 10,000nM). |
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