TAK-220
Cat. No. :YN321259
CAS No. :333994-00-6
Pack size
price
inventory
5mg
Enquiry
Enquiry
10mg
Enquiry
Enquiry
25mg
Enquiry
Enquiry
50mg
Enquiry
Enquiry
86-020-82000279
sales@ubiochem.com
order@ubiochem.com| Product Name: | TAK-220 |
| CAS NO.: | 333994-00-6 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 553.14 |
| Molecular Formula: | C₃₁H₄₁ClN₄O₃ |
| SMILES: | O=C(C1CCN(C(C)=O)CC1)N(CCCN2CCC(CC3=CC=C(C(N)=O)C=C3)CC2)C4=CC=C(C)C(Cl)=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | TAK-220 is a selective and orally bioavailableCCR5antagonist, with IC50s of 3.5nM and 1.4nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibitsHIV-1, with EC50s of 1.2nM (HIV-1 KK), 0.72nM (HIV-1 CTV), 1.7nM (HIV-1 HKW), 1.7nM (HIV-1 HNK), 0.93nM (HIV-1 HTN), and 0.55nM (HIV-1 HHA), and EC90s of 12nM (HIV-1 KK), 5nM (HIV-1 CTV), 12nM (HIV-1 HKW), 28nM (HIV-1 HNK), 15nM (HIV-1 HTN), and 4nM (HIV-1 HHA) in PBMCs. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
TELL : +86-020-82000279
Add:Room 519, Block F, Guangzhou International Business Incubator, No.3 Lanyue Road, Science Town, Huangpu District, Guangzhou, China.
