KT5823
Cat. No. :YN310371
CAS No. :126643-37-6
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order@ubiochem.com| Product Name: | KT5823 |
| CAS NO.: | 126643-37-6 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 495.53 |
| Molecular Formula: | C₂₉H₂₅N₃O₅ |
| SMILES: | C[C@@]([C@@]1(OC)C(OC)=O)(O[C@](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with anKivalue of 0.23μM, it also inhibits PKA and PKC with Ki values of 10μM and 4μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I-symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels ofapoptoticDNA fragmentation. |
| IC50&Target: | |
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| Solvent & Solubility: | |
| References: |
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