PF-3450074
Cat. No. :YN250295
CAS No. :1352879-65-2
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order@ubiochem.com| Product Name: | PF-3450074 |
| CAS NO.: | 1352879-65-2 |
| Chemical Name: | |
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| Molecular Weight: | 425.52 |
| Molecular Formula: | C₂₇H₂₇N₃O₂ |
| SMILES: | O=C(N[C@@H](CC1=CC=CC=C1)C(N(C)C2=CC=CC=C2)=O)CC3=C(C)NC4=C3C=CC=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | PF-3450074 (PF-74) is a specifical inhibitor ofHIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153. |
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