Leu-AMS
Cat. No. :YN250172
CAS No. :288591-93-5
86-020-82000279
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order@ubiochem.com| Product Name: | Leu-AMS |
| CAS NO.: | 288591-93-5 |
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| Molecular Weight: | 459.48 |
| Molecular Formula: | C₁₆H₂₅N₇O₇S |
| SMILES: | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)CC(C)C)=O)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor ofleucyl-tRNA synthetase(LRS) with an IC50 of 22.34nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria. |
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