MAC-545496
Cat. No. :YN250442
CAS No. :838810-96-1
86-020-82000279
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order@ubiochem.com| Product Name: | MAC-545496 |
| CAS NO.: | 838810-96-1 |
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| Molecular Weight: | 419.89 |
| Molecular Formula: | C₁₈H₁₈ClN₅O₃S |
| SMILES: | O=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model. |
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