Manumycin A
Cat. No. :YN321769
CAS No. :52665-74-4
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order@ubiochem.com| Product Name: | Manumycin A |
| CAS NO.: | 52665-74-4 |
| Chemical Name: | |
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| Molecular Weight: | 550.64 |
| Molecular Formula: | C₃₁H₃₈N₂O₇ |
| SMILES: | CCCC[C@@H](C)/C=C(C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of proteinfarnesyltransferase (FTase)with respect to farnesylpyrophosphate (Ki=1.2μM), and as a noncompetitive inhibitor with respect to theRasprotein. Manumycin A inducesapoptosis and exerts antitumor activity . Manumycin A suppressesexosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A is anSMaseinhibitor (EC50=0.25μM).. |
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