(±)-Praeruptorin A
Cat. No. :YN360908
CAS No. :73069-25-7
86-020-82000279
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order@ubiochem.com| Product Name: | (±)-Praeruptorin A |
| CAS NO.: | 73069-25-7 |
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| Molecular Weight: | 386.40 |
| Molecular Formula: | C₂₁H₂₂O₇ |
| SMILES: | C/C=C(C)C(O[C@H]1[C@@H](OC(C)=O)C2=C3C(C=CC(O3)=O)=CC=C2OC1(C)C)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Praeruptorin A may exert antiinflammatory effects in vitro in LPS-stimulated RAW 264.7 macrophages through inhibition of NF-κB signal pathway activation. Praeruptorin A and praeruptorin C can significantly up-regulate UGT1A1 expression in HepG2 cells partially via the CAR-mediated pathway. (+)-Praeruptorin A exerts distinct relaxant effects on isolated rat aorta rings, which may be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase. dl-Praeruptorin A has a neuroprotective effect on the injury in the acute phase of transient focal cerebral ischemia in mice,with optimal doses of 5 mg/kg and the optimal therapeutic time point of the same time of reperfusion. dl-Praeruptorin A elicits a novel target in the therapeutic prevention of postischemic cardiomyocyte death, the reason might be associated with modulating the expression of some immediate-early genes including IL-6, Fas, bax, and bcl-2 in ischemia-reperfusion myocardium. Praeruptorin A upregulates expression of nestin in experimental autoimmune myocarditis of rats, it is beneficial to facilitate nestin expression in myocarditis,and suitable in treatment of early myocarditis. Praeruptorin A has anti-osteoclastogenic activity via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. |
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