Harpagide
Cat. No. :YN251482
CAS No. :6926-08-5
86-020-82000279
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order@ubiochem.com| Product Name: | Harpagide |
| CAS NO.: | 6926-08-5 |
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| Molecular Weight: | 364.35 |
| Molecular Formula: | C₁₅H₂₄O₁₀ |
| SMILES: | O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2OC=C[C@]3(O)[C@@]2([H])[C@](O)(C)C[C@H]3O)O[C@@H]1CO |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Harpagide and harpagoside are two iridoid glycosides existing in many medicinal plants, they are believed to be the main bioactive compounds related to the anti-inflammatory efficacy of these plants, the hydrolysis of the glycosidic bond of them is a pre-requisite step for their COX-2 inhibitory activity. Harpagide and Harpagoside have protective effects on human vascular endothelial cells(HUVECS) injury induced by hydrogen peroxide(H2O2). Harpagide has neuroprotective effect, it can obviously protect acute cerebral ischemia in mice,its therapeutical effects are approached to protecting the activity of brain mitochondria and decreasing protein expression level of caspase-3. Harpagide has a potential for prevention of bone loss in ovariectomized (OVX) mice by regulating the stimulation of osteoblast differentiation and the suppression of osteoclast formation. |
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