Lagociclovir
Cat. No. :YN250603
CAS No. :92562-88-4
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order@ubiochem.com| Product Name: | Lagociclovir |
| CAS NO.: | 92562-88-4 |
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| Molecular Weight: | 269.23 |
| Molecular Formula: | C₁₀H₁₂FN₅O₃ |
| SMILES: | O=C(N=C(N)N1)C2=C1N([C@@H]3O[C@H](CO)[C@@H](F)C3)C=N2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. Oral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and , importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. |
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